MALDI成像

您的研究是否专注于plant metabolomics，，，，biochemistry of cellular processes，，，，biomarkers of disease development or treatment，，，，或微生物相互作用，，，，MALDI成像can deliver new insight to your work. Key to this is the ability to integrate MALDI Imaging with other imaging modalities you may already be using, such as fluorescence microscopy or histology.

布鲁克pioneered this capability in 2005 by allowing the importation and registration of other images into the MALDI Imaging dataset with full visual overlay.

Application areas for MALDI Imaging are diverse and growing, driven by the label-free nature of the technique and the ability to differentiate compounds by molecular weight. Untargeted discovery studies such as those in clinical research seek to uncover novel biomarkers of disease and treatment. For maximum information with intelligence use MALDI guided SpatialOMx®. MALDI Imaging is also revolutionizing pre-clinical drug discovery pipelines by providing direct distribution monitoring of therapeutic compounds and their metabolites.

这是两个例子未定位or有针对性的方法Maldi成像已被证明有价值的地方。可以看到围绕植物，聚合物和微生物的新应用在科学文献中出现，在该科学文献中，布鲁克的Maldi成像技术已被证明是有价值的。

使用MALDI在空间测量分子特征
超过25年,力量是领袖in MALDI mass spectrometry innovation. MALDI is amenable for any analytical task and this is exemplified in the scientific literature where MALDI Imaging publications dominate 5:1 over the next ionization technology. Bruker delivers MALDI Imaging systems that incorporate novel MALDI technologies to accomplish any targeted or untargeted imaging study.

空间定向分子特征
图像是通过以应用于样品表面的虚拟网格模式收集MALDI数据来生成的。将样品的薄部分安装到导电载玻片上，并通过气溶胶施加一层MALDI基质。Bruker的MALDI成像技术允许用户使用样品的数字图像直接定义测量区域和分辨率。虚拟网格的大小建立了图像分辨率，并针对要回答的实验问题量身定制。

Given each MALDI spectrum is acquired from a discrete virtual grid without oversampling, the resulting dataset is a molecular signature of the unique area sampled. Unlike ionization systems which utilize oversampling, Bruker’s MALDI Imaging technologies produce ion images which do not exhibit image ‘blurring’.

对于有针对性和非目标的成像研究，布鲁克的SolarixandscimaX®磁共振质谱仪(MRMS) offer eXtreme mass resolution. At imaging speeds, achieve> 290,000个质量分辨率为m/z 400能够区分和映射化合物仅通过几个MDA。

这Timstof Flexoffers versatility needed for SpatialOMx®. Built on Bruker’s pioneeringtimstof proTimStof Flex的平台为您的所有X-Momics分析提供了动力，同时添加了高空间分辨率MALDI成像源，以为OMICS分析提供空间维度。将蛋白质组学分析转化为空间蛋白质组学，脂质组学和代谢组学变成空间代谢组学-PatialOMX®。

Our software solutions make it easy to start with MALDI Imaging. TheScils自动驾驶例如，是一种新的软件工作流程，用于依靠布鲁克的简单且可重复的MALDI成像测量设置Intellislides™。这automated steps save time and reduce manual user input increasing reliability and reproducibility of the measurement regardless of users’ expertise.

这automated workflows are available for the timsTOF fleX,Timstof Flex Maldi-2和Rapiflex。请在此处下载Quickstart指南Timstof Flexincluding MALDI-2andrapifleX。