代谢组学在理解传统中药的作用

Traditional中药(TCMs) are widely used throughout the world in the prevention and treatment of viral pneumonia through the belief in their potential to boost the body's resistance to the pneumonia virus and modulate its immune response. Many viruses have established sophisticated mechanisms to interact with the host immune system.

TCMs have been shown to enhance antibody production and T cell proliferation, and the expression of antigen-specific responses.[i] TCMs, composed of various kinds of medicinal plants, animals and minerals in the form of oral liquid, powder and granules, have been reported to achieve certain therapeutic effects but their mechanism remains unclear.

OMICS技术是TCM研究中的宝贵工具。特别是代谢组学是一种新的逻辑方法，可以帮助定位功能性的小分子来评估TCMS的药理作用。[ii]对体内特定细胞过程的代谢概况进行的系统研究，代谢物可以提供有用的信息来提供有用的信息来帮助帮助患者的诊断和预后以及预测对特定干预措施的药理反应。

作为一种理解疾病的新方法，代谢组学在血浆，血清和尿液等生物学样本中的所有代谢物中提供了“快照”。最近的报道表明，代谢组学分析可能会使临床医生有机会识别新的生物标志物，以供详细表型及其在病毒肺炎中进展。[III]

代谢组学有助于理解在不同种类的生理和病理条件下完整系统的代谢变化。代谢组学的这种特性与TCM的整体思维一致，这表明它有可能提高我们对基于证据的TCM背后理论的理解。

近年来，越来越多的代谢组学研究检查了TCM治疗病毒性肺炎后的代谢谱。TCM治疗后，代谢物并发现了各种生物标志物和扰动途径。

一项研究[V]研究了八个已发表的代谢组学和TCM提取物相关文章，以发现几种不同的代谢物，包括甘油三酸酯，氨基酸和碳水化合物，在病毒性肺炎组中受到干扰。这项研究的代谢组学数据表明，活性化合物和草药，例如Baicalaria georgi，Polygonum cuspidatum sieb。ET ZUCC，Flos Lonicerae Japonica和Forsythiae有效地对抗病毒肺炎。列出了五种已发表的代谢组学和与TCM公式相关的物品，并发现17种与TCM相关的植物物种，发现四个TCM配方可有效地对抗病毒性肺炎。

Metabolomics is a top-down strategy to reflect the function of living organisms from the end products of the metabolic network.[vi]

It is set to be a powerful approach to support TCM research in the future. Current research on TCM is still in its infancy because of the multi-component mixtures that often possess their own inherent holistic bioactivities. At Bruker, we believe that metabolomics-pharmacological research supported by our cutting-edge, integrated metabolomics solutions will see exciting developments as the ancient tradition of TCM is brought to the light of science.

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Jong Seok L，Kyoung CM，Hye Suk H，Eun-Ju K，Yu-Na L，Young-Man K，Min-Chul K，Ki-Hye K，Young-Tae L，Yu-Jin J. Ginseng J. Ginseng J. Ginseng降低了肺病在挑战后通过调节宿主免疫反应后，用福尔马林灭活的呼吸道合胞病毒免疫的小鼠。J干扰素细胞因子Res。2014; 34：902-14。

Wang KC，Chang JS，Chiang LC，Lin CC。Sheng-Ma-Ge-gen-Tang（Shoma-Kakkon-to）抑制了人呼吸道合胞病毒在人呼吸道细胞系中的细胞质病作用。J Ethnopharmacol。2011; 135：538-44。

Lin-Lin M，Miao G，Hui-Qiang W，Jin-Qiu Y，Jian-Dong J，Yu-Huan L.几种针对流感病毒的口服传统中药的抗病毒活性。基于EVID的补体替代药物。2015; 2015：1-9。

[ii] Sun X，Song L，Feng S，Li L，Yu H，Wang Q，Wang X，Hou Z，Li X，Li Y.脂肪酸代谢与H7N9感染后的疾病严重程度有关。ebiomedicine。2018; 33：218-29。

Banoei MM，Vogel HJ，Weljie AM，Kumar A，Yende S，Angus DC，Winston BW。血浆代谢组学用于H1N1流感肺炎的诊断和预后。残疾人护理。2017; 21：97。

Lu C，Jiang Z，Fan X，Liao G，Li S，He C，Han L，Luo S，Liu Y，Lin H.一种用于评估流感A（H1N1）患者的治疗评估的代谢方法。塔兰塔。2012; 100：51-6。

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[iv] Meng X. Regularity of compound herbal formula for pneumonia treated by Professor Wang Shouchuan and anti-RSV effect of Jinxin oral liquid and baicalein based on metabolomics. NJUCM. 2017.

[v] Lili Lin，Hua Yan，Jiabin Chen，Huihui Xie，Linxiu Peng，Tong Xie，Xia Zhao，Shouchuan Wang和Jinjun Shan（2019）代谢组学在病毒性肺炎治疗中使用传统中药，中国：Springer自然。

[vi] Zhang A, Sun H, Wang Z, Sun W, Wang P, Wang X. Metabolomics: towards understanding traditional Chinese medicine. Planta Med. 2010;76:2026-35.