制药与生物制药

知识产权

强烈保护知识产权作为长期研究和可持续投资的刺激。

Why do we value intellectual property?

Patent expiration is a threat for pharmaceutical industry and an opportunity for generic companies. On average, the revenue of pharmaceutical drugs decrease by 90% 3 years after their patent expires. There are several approaches to line extension such as combination of drugs, new applications, dosage, a new isomer and a new solid form or formulation.

强大的知识产权以药物专利形式保护为公司提供漫长而昂贵的投资的激励措施，最终导致医疗进步并为未来的研究提供资金。

通过应用固体形式的专利方法，可以将额外的保护层添加到药物药物专利中 - 通过包括与固体形式相关的其他索赔，或提交与初始药物专利有关的其他固体形式专利。在这里，固体形式一词是指结晶（多晶型物，水合物，溶剂，盐，共晶）和无定形材料（无定形药物，无定形的固体分散剂和co-Ororprous）。bob综合游戏由于通常在初始药物药物专利之后提交固体形式专利，因此它们还具有稍后到期日期的潜力。

这种策略的潜在成功是基于非明显和新颖性的。对于任何化合物，都不可能预测有多少不同的固体形式或它们的特性。此外，从定义上讲，从本质上讲，每种新的固体形式都是新颖的。结果，几乎每种新的固体形式都可能是一个可专利的实体。

布鲁克is providing a comprehensive range of analytical systems for solid form characterization and thus for the definition of strong patent claims as well as subsequent protection of the patent. X-ray diffraction (XRD) data are generally considered essential to characterize claimed forms, often along with complementary Infrared (IR), Raman, and/or solid-state nuclear magnetic resonance (NMR) data for further characterization.

布鲁克Solutions

独特,XRD直接探针分子的安排ement in solid forms. XRD is therefore the tool of choice for crystal structure analysis and related property characterization of any forms that may occur. XRD powder patterns and derived peak lists are fingerprints allowing to verify the polymorph identity of a given crystal form, whether as a single phase or within a mixture of other solid materials and to quantify its abundance in mixtures. XRD fingerprints also allow to determine the polymorphic purity of a given sample, and to quantify the abundances of different polymorphs. Consequently, XRD fingerprints are often considered a gold standard for characterizing solid materials and are commonly used for the definition of patent claims as well as for patent protection.

固态NMR是一种互补技术，可以在固体表征中解决任何潜在的疑问。它可以衡量放松的时间，以唯一说出固体形式。当需要更高的分辨率或无定形形式的分析和定量时，固态NMR特别相关。作为一种强大的信息丰富的技术，提供了宝贵的结构信息，以提高您对药物和药物产品的固体表征的水平信心。

布鲁克高端仪器以固体形式阐明，通过多种技术从多个角度提供答案。完全表征和准确的量化确保质量，同时确保您的市场权利。数百万是由吸毒者和仿制药公司花在知识上的涉及坚固形式的财产诉讼。发生这种情况时，您希望手中最好的数据！