TargetScreener HR

Proven to minimize false positives
使用所有信息消除虚假正面和假阴性识别以实现明确的识别的重要性不能过分压力。

Reliance on precursor accurate mass and retention time alone can lead to a high number of false positive/negative results.

Mass spectra also contains very informative isotope patterns and characteristic fragmentation patterns and by utilizing the full data content available, false positives and false negatives are essentially eliminated.

可以通过使用宽带CID（BBCID）数据采集扫描模式来获得这种广泛的数据集，以在整个实验过程中连续生成高分辨率准确的质量父离子，真实的同位素模式强度和碎片预选赛。将所有这些数据结合在一起并添加保留时间信息与TargetScreener HR意味着实际上消除了假阳性检测，从而对您的筛查结果产生了最大的信心。

During the screening process, the QTOF mass spectrometer rapidly and continuously cycles between low collision energy (TOF-MS) and elevated collision energy (bbCID) MS/MS, resulting in the seamless collection of accurate mass precursor and fragment ion data in a single analysis.

At the heart of the TargetScreener solution is the exact mass pesticide database. In addition to high resolution monoisotopic precursor ion masses and retention time data, the database also contains up to ten high resolution diagnostic qualifier ion information, comprising of accurate mass bbCID fragments and 'in source' fragment ions as well as adduct and isomer information.

版本4.0在目标屏幕仪HR解决方案中添加了几个关键功能：

• Flexibility of using both targeted and non-targeted workflows in routine and research environments
• Power to confidently answer questions “what else is in the sample?” and “what is the difference between samples?” with non-targeted data acquisition, analysis, and retrospective data mining

• 同时使用LC和GC分离以及在UHPLC-QTOF和GC-APCI-QTOF工作流程之间切换的适应性
• Expanded database of drugs, pesticides, and environmental pollutants for both LC and GC workflow
• 用于水分析的新数据库，其中有近400个条目涵盖了欧洲法规所需的所有化合物

分析复杂的体液的存在drugs and/or toxicants together with their associated metabolites is a challenging application especially when ‘getting it right first time’ is of major importance. TargetScreener HR is designed to meet these challenges and either accurately report which drugs/toxicants are present in the sample, or if no matches are found in the database, then provide several key pieces of analytical data and information to give the best chance of elucidating an identification.

TargetScreener人力资源 - 获取完整视图
TargetScreener HR is designed specifically for use with Bruker QTOF mass spectrometers to enable comprehensive targeted forensic screening and clinical screening, confirmation and quantitation of drugs and other toxicants in human body fluids. The solution is highly automated and hence minimizes method development time for toxicological screening.

的核心TargetScreener人力资源是一个high-quality forensic database of over 2,000 compounds of forensic relevance. The high resolution (HR) database includes exact mass data for parent ions, adducts, fragment ions as well as isotopic pattern and retention time information delivering maximum confidence in the end result and with a total injection to injection analysis time of 20 minutes.

为了增加灵活性，用户可以轻松地在HR-MS数据库中添加新化合物，从而使未来几年的投资未来，并提供对先前分析的样本进行回顾性分析的能力。

针对新的精神活性物质（NP）
The ability to add new compounds to the HR-MS database using a standardized protocol is particularly pertinent given the explosion in the number of new synthetic cannabinoids hitting the drug scene. Given that TargetScreener HR collects ‘all of the data, all of the time’, all data files contain all the information required to retrospectively re-screen a previously analyzed sample when new compounds have been added to the database.

Should a positive ID still not be achieved, the mass spectra of an unknown peak will contain pseudo molecular ion accurate mass information, true isotopic ion (TIP – registered trade mark) for elemental composition and accurate mass fragment ions thus allowing the best chance of elucidating a chemical structure.

Furthermore, significant advances within Bruker’s QTOF instruments have resulted in systems which are both very sensitive and possess a large linear dynamic range in their response thus making them eminently suitable for quantitative studies.

Collectively, these benefits make TargetScreener HR the most powerful tool for in-depth forensic analysis.