TargetScreener HR

第一次做正确的
Analyzing complex food/water samples for drugs, pesticides or mycotoxins, or equally challenging human/animal urine, saliva, or serum samples for poisons or drugs, is a demanding application. TargetScreener HR is a powerful solution based upon accurate mass analysis with Bruker QTOF systems and highly curated databases (over 2800 compounds) to ensure reporting false positives (or false negatives) is minimized. Obtaining highly accurate quantitative data is also assured with TargetScreener HR.

Added to the powerful mass spectrometer system are TargetScreener HR integrated software algorithms, methods, columns and databases to allow it to work ‘out of the box’.

使用“基于异常”算法的智能数据审查
用于筛选和定量的数据处理由TASQ®（用于筛选和定量的目标分析）软件提供动力。TASQ®智能地使用诊断预选赛离子来减少误报检测，从而为筛查工作流带来新的信心。

For total confidence in the results, four dimensions of confirmation are used in the TargetScreener HR workflow:

• Parent ion or adduct exact mass
• Retention time
• Isotopic pattern fidelity
• Exact mass of fragment qualifier Ions

Color coded screening results are easily reviewed in either a sample centric or analyte centric fashion as desired by the analyst. Once reviewed, qualitative and quantitative sample reports are then easily generated.

TargetScreener在完整的扫描MS和MS/MS模式下检测“所有离子，所有时间”，而不会损害灵敏度或分辨率，从而导致完整且不受限制的数据集。然后，诊断预选赛离子可以用作增强确认标准的一部分，以消除假阳性发现，并提供无歧义的ID，用于共同洗脱同质药物。

Key reasons for implementing TargetScreener HR
Using TargetScreener HR means that within the analytical run time of 20 minutes the system collects ‘all of the data, all of the time’ thus providing retrospective and unknown identification capabilities. Hence, if previously run samples are required to be screened for new compounds of interest then a simple operation allows this without the need to reinject the sample.

The highly curated large database provides the highest chance of eliminating false positive and false negative rates by using resolution, accurate mass, isotopic patterns, adducts and bbCID fragmentation patterns and comparing to the acquired data. The system is also highly sensitive and quantitative for use in food safety or drugs of abuse work and required legal limits of detection.

TargetScreener HR is extremely powerful for in-depth, investigative screening and quantitation as well as retrospective data mining.

Automated workflows to exceed MRLs
在各种复杂矩阵中分析符合调节性最大残留限度（MRL）水平的食物污染物是一个挑战，目标屏幕范围是HR擅长的。食品和水分析经常提出类似的挑战，在这种挑战中，经常遇到农药和激素等复合类别。TargetScreener HR内部的功率轻松应对此类挑战。

农药分析和食物污染物筛查
Using pesticides to reduce crop damage and to increase horticultural productivity has been implemented on a global scale for many years and, due to their toxicity, the potential migration of these chemicals into the human food and water supply chains presents considerable health concerns. Therefore, the MRL permitted for pesticides in food; feeds and water are strictly controlled by local and international regulatory bodies.

TargetScreener HR是专门设计的，可以通过确保在数据采集期间，从UPLC柱中洗脱的所有化合物都具有分子离子数据和片段化光谱。因此，没有错过任何复合。这是通过在不同的扫描模式之间迅速循环来实现的，以确保单个数据集中的前体和片段离子数据的无缝集合。

Such a dataset contains pseudo molecular ions, adduct ions, fragment ions and isotopic pattern together with their retention time. All this information is used by the database to provide enhanced levels of compound identification and hence dramatically minimize the potential for false positive of false negative results. Measurement of the precursor accurate mass and retention time alone can lead to a high number of false positive results, particularly with complex matrices such as QuEChERS extractions.

All detected compounds can then be quantified against their MRL and reports generated with a high level of confidence.

Using TargetScreener HR allows over2000 compounds to be accurately screened and quantified in water and food analysisensuring the presence of contaminants are accurately reported.