BioScope Resolve
Destaques
BioScope Resolve
Bruker的Bioscope Resolve bioafm具有最高分辨率原子显微镜成像和最完整的细胞力学功能，可与倒光学显微镜一起使用。Bioscope Resolve融合了Bruker的独家峰值攻击技术，使研究人员能够在每个像素上实现最高分辨率的生物成像和Piconewton级的力量测量和光谱。该系统对光学和原子力显微镜数据的实时同步为先前无法接近的数据打开了大门，包括物理结构，生化相互作用和机械性能，以提供对生命科学研究的独特见解。
Características
Accurate, Repeatable, and Complete Cell Mechanics Data
Ultimate force control—PeakforceQNM®, has become the preferred mode for nanomechanical mapping. With new algorithms, it delivers highest resolution property maps at pN forces on live cells. Together with “No Touch” tip calibration, PeakForce QNM delivers the fastest quantitative mechanical characterization of live cells, providing a complete force curve for every pixel at actuation rates from 125 Hz to 2 kHz.
Widest range of ramp rates— At the core of quantitative nanomechanical maps are force-distance curves. Beyond characterizing elastic response, ramp rate dependent data provides insight into viscoelasticity or into molecular interaction times at the single molecule level. With our newFASTForce Volumecovering rates from sub-Hz to 300 Hz, andPeakForce Tapping扩展到2 kHz, we provide the widest range of ramp rates for single points and imaging while maintaining pN force control.
Covering the whole spectrum- 我们的新RampScript™允许用户构建，控制和记录复杂的纳米力学测量值，用于用于蛋白质拉，配体 - 受体相互作用，细胞松弛和粘弹性探测。其低力触发功能，无延迟实现在系统的核心性能上建立，以提供最准确的脚本执行和力控制。坡道脚本是在直观的拖放过程中创建的，并提供了最终的灵活性，包括每个段光学同步。
Cell Dynamics Without Compromise
Fast Tapping on living cells- Bioscope Resolve is the only BioAFM that enables fast scanning while simultaneously providing the large piezo scanner range necessary for capturing the dynamic behavior of living cells in real time (XYZ = 100µm x 100µm x 15µm). The Fast Tapping capabilities of Resolve are truly a step forward in conducting high-resolution AFM studies at timescales relevant to cellular processes. Together with the integration of advanced optical microscopy and environmental control, live cell studies have never been easier.
Seamlessly Combined Fluorescence and Biomechanics
Expanded measurement possibilities— The MIROView GUI ensures expert data generation via fully synchronized AFM images, force maps, and single-force curves with optical images and data.
Great optical integration— BioScope Resolve AFM works seamlessly with an optical microscope, thanks to communication protocols developed with researchers’ applications in mind. Pixel by pixel, line by line, and image by image, optical synchronization delivers flexibility never seen before on an AFM.
The perfect environment- 带有新的声学罩，工作站以及一套完整的生命科学研究配件，例如样品加热器，灌注电池和自上而下的相机，Bioscope Resolve可提供您所有的生物适应性研究需求。
Aplicações
BioScope Resolve Data Gallery
Acessórios
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Hear What Our Customers Have to Say
It was previously impossible to resolve the finest structures of a live cell like microvilli, but now with the improved PeakForce Tapping on BioScope Resolve, I can Image them easily on one hour.
For the first time, bio-AFM analysis can directly correlate high-resolution molecular structures with function, on the same cell. BioScope Resolve provides the dynamic range and resolution necessary to allow a deeper understanding of structure-function relationships at the cell and tissue surface.
With the unique capabilities of PeakForce QNM and the versatile operation modes on our BioScope AFM, we are ready to extend our micro- and nano-robotic manipulation research of biological samples with ultrahigh resolution.
