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Punti Salienti

400 MHz

The AvanceCore is a full-fledged, two-channel 400 MHz NMR spectrometer.

成本效益

可以通过软件订阅灵活启用和禁用其他功能。您只需要在需要的时候支付所需的费用。

Quality & Performance

The AvanceCore offers the quality and high performance Bruker is known for, now at a lower price.

More Information on the AvanceCore NMR Spectrometer

下载

NMR如何负担得起？计算底线！

该计算器旨在为客户提供每天大于5个样本。考虑到投资Avancecore NMR光谱仪的成本，相关的运行成本以及您合作的样本数量，我们为您提供了每次测量平均成本的估算。

AvanceCore Calculators

What is my ideal AvanceCore configuration and when will my investment pay off?

This calculator is especially suited for customers withless than 5 NMR samples per day。摊销计算器比较了在Avancecore NMR光谱仪中投资的成本与使用外部NMR服务提供商的成本。bob电竞官方网站我们计算您将看到投资回报的时间。

AvanceCore Calculators

卡特里斯蒂奇

Features

NMR是一种非常强大的分析方法。结合Avancecore的可负担性，这使NMR成为解决各种分析问题的理想工具，包括结构阐明和验证，分子相互作用和定量。Avancecore解决方案以类似于标准液相色谱质量规格仪器的价格提供NMR。

Benefici

好处

NMR offers many advantages over other analytical techniques. The AvanceCore provides better value for money than other methods:

With NMR, what you see is what is present. Chromatographic analysis requires process steps such as liquid injection or sample evaporation. Potential sample degradation or unwanted reactions complicate the assignment of signals.
NMR选择性检测核等核¹H,¹³C，¹⁹f和³¹P中存在于有机分子中。对于其他分析技术，这并不明显。例如，色谱紫外线检测器错过了许多没有发色团的物质。IR和质量探测器具有相似的局限性。
With NMR, substances can be identified and quantified against any reference standard. Other analytical methods rely on a reference standard of the same material.
1D NMR experiments can be run with standard parameters for most samples. Several compounds are identified and quantified from a single spectrum. HPLC, for instance, can also deliver good separation and signal-to-noise — provided that the method was optimized for the particular application. NMR helps you to save time and money.

Applicazioni

Applications

AvanceCore NMR Sample Preparation and Measurement

你知道核磁共振样品制备可以吗easy as dissolving a few milligrams of sample substance in 0.6 ml of solvent? The actual measurement can be done in full automation, takes approximately 5 minutes, and requires no dedicated staff. NMR with a Bruker AvanceCore is a very robust, reliable, versatile and cost-effective analytical technique!

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How to Read and Interpret NMR Spectra in 15 Minutes

当今关于化学和分子结构的知识是不可想象的，没有NMR。NMR对化学的贡献得到了两项诺贝尔奖的荣誉，对于制药，化学药品和天然产品的开发和制造是必不可少的。

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Direct Assignment of the Carbon Backbone with Room Temperature Probes at Medium Fields: The INAD NMR experiment

NMR实验不足可促进有机分子通过碳主链的直接结构分配。这比其他间接方法具有优势。了解如何使用24小时的室温探针以400 MHz记录实验 - 即使样品物质量有限。

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Avancecore具有很高的成本效益，并促进了高分辨率NMR的不妥协性能。出色的分散和信噪比将混合分析降低到PPM浓度。Avancecore支持最先进的2D NMR方法，以阐明原子水平的分子结构。

Identification and quantitation: The above 1H spectrum was acquired with the AvanceCore Foundation from a 20 mg sample in less than 5 minutes. The sample contains 100 ppm (0.002 mg) of the following impurities: acetonitrile, acetone, ethyl acetate and acetic acid in DMSO-d6.

The AvanceCore Foundation also supports state-of-the-art 1H-1H 2D experiments such as TOCSY, COSY, ROESY and NOESY. The above spectrum shows TOCSY-correlations of the anti-inflammatory drug Ibuprofen.The TOCSY can be used for structure assignment.

使用Avancecore基金会，可以进行1H滴滴NMR实验用于混合分析。Dosy通常称为“色谱NMR”。就像LC-MS一样，它可以分辨出不同的混合物成分的不同质量和扩散特性。

The AvanceCore Select supports heteronuclear experiments (HSQC, HMBC...) which are essential for molecular structure elucidation. The above spectrum shows a 2D 1H/13C HSQC-TOCSY experiment recorded from a 20 mg Ibuprofen sample.

特定

Configurations

为了保持低廉的成本，Bruker将Avancecore简化为三个预先配置的包裹。

Foundation:在最基本的版本中，Avancecore提供高分辨率¹H NMR光谱法。该捆绑包包括400 MHz NMR磁铁，控制台和5 mm探针。

Select:Avancecore选择包括所有的硬件和软件¹Hand heteronuclear (¹³C，³¹P ...）最新的实验。

方便：The AvanceCore Convenience includes a 24-position sample changer. The IconNMR software enables open access use and automated routine measurements.

Your instrument can grow with your needs: An existing AvanceCore can easily be upgraded from Foundation to Select and from Select to Convenience.

规格

The AvanceCore is a complete, full-fledged 400 MHz NMR-spectrometer. The AvanceCore spectrometer has the following key characteristics:

Avancecore磁铁	NMR-frequency (¹H)	400 MHz
	Typical helium hold time	300天
	Typical nitrogen hold time	16天
Avancecore控制台	RF频道的数量	2
	定时解决	12.5 ns
	Frequency Resolution	< 0.005Hz
	数字锁	Included
	RF amplifier frequency range	⁵⁷fe¹⁹F/¹H
AvanceCore Probe	NMR管直径	5毫米
	Channels	¹H, BB &²HLock
	Z级别	50 G/cm
Available Accessories	Sample Temperature Control Unit, 24-position Sample Changer

Testimonianze

Dr. Johan Lindström, Director Medicinal Chemistry Sprint Bioscience

“Our new Bruker AvanceCore NMR spectrometer will play a key role in our mission to make a meaningful difference in the fight against cancer by providing innovative drug candidates to the pharmaceutical industry. As we strive to broaden our portfolio with high-quality projects as resource and cost-efficiently as possible, the more affordable AvanceCore is a perfect fit for us. We get the high quality of a Bruker NMR system while keeping our investments low."

Dave McGowan, Associate Director Medicinal Chemistry

阿里戈斯治疗学

“在Aligos，我们正在开发针对NASH的靶向疗法，以及用于慢性乙型肝炎和Covid-19的抗病毒药，Bruker Avancecore光谱仪的负担能力使我们现在可以在内部进行高分辨率的NMR分析，而不是必须外包。。这使我们的流程更加有效，并大大加快了我们的研究工作。”