IP2Accelerates CCS-enabled 4D-Proteomics™ with GPU-based Scalable Search Engine
IP2为Timstof®蛋白质组学系统添加了“运行与完成”的实时功能
马萨诸塞州比勒里卡（Billerica） - （商业资讯） -Bruker Corporation（纳斯达克：BRKR）宣布最近收购集成蛋白质组学管道（IP2) search engine and proteomics workflow software platform.IP2是由综合蛋白质组学应用Inc开发的，该公司由领先的蛋白质组学研究员约翰·耶茨三世（John Yates III）与博士一起开发。罗宾公园和陶徐。交易的财务细节未披露。
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约翰·耶茨（John Yates III）教授，Scripps研究所（照片：商业资讯）
此次收购进一步增强了Bruker对CCS启用4D-Pototomics™的解决方案，通过添加快速，可扩展和GPU的搜索引擎功能，以更快的数据处理和分子碰撞横切（CCS）的全面利用。好处包括更大的数据完整性以及对蛋白质和PTM识别率的更高信心以及无偏的“射击”蛋白质组学中的量化。布鲁克的小说Timstof在PASEF模式下具有> 120 Hz占空比的质谱系统非常适合通过在多个线程上通过启用GPU的并行操作实时搜索。
“Partnering with theIP2team and the Yates Lab provides an excellent opportunity to enhance Bruker’s bioinformatics capabilities in support of 4D-Proteomics™,” said Dr. Rohan A. Thakur,Bruker’s Executive Vice President for Life Science Mass Spectrometry. “High-throughput proteomics requires unprecedented search engine performance, including the need for low false discovery rates with very large datasets. This will benefit the proteomics research and translational medical community. We are also pleased to announce the establishment of Bruker’s bioinformatics team focused on protein and data science based in San Diego, California, headed by Robin Park who joined Bruker as part of theIP2asset acquisition. Robin will continue to work closely with the Yates Lab in his new role with Bruker, as well as with other Bruker open proteomics software partners and collaborators.”
“We are very pleased to partner with Bruker in enabling a CCS-aware bioinformatics platform,” added Professor John Yates III, the Ernest W. Hahn Professor at The Scripps Research Institute in La Jolla, California. “Innovative software tools are a necessity to address unanswered biological questions with mass spectrometry. The trapped ion mobility functionality and the robustness of thetimstof prooffer unique bottom-up proteomics capabilities that can be effectively used to study many diseases. For example, a current focus of our research is to further our understanding of proteins involved with brain disorders, such as Alzheimer’s Disease (AD) and Autism Spectrum Disorders (ASD).”
“TheTimstof已经迎来了快速纳米LC的时代，每个乐器每天都会每天运行五十多个4D Proteomics™，但将瓶颈推向数据分析，” Gary Kruppa博士说。,布鲁克蛋白质组学副总裁。“独特IP2GPU搜索引擎具有大量数据量的大量数据量，可实现“运行与完成”的蛋白质组学，并在获取大型数据集后立即获得结果。而且，有IP2we expect to enable a new paradigm whereTimstof获取将搜索结果作为反馈实时的反馈，以关注感兴趣的蛋白质，以获得更完整的定量结果。最后，IP2offers an optional gateway for our other proteomics software partners to accelerate their time-to-results.”
About Bruker Corporation（纳斯达克：BRKR）
Bruker is enabling scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. Bruker’s high-performance scientific instruments and high-value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity and customer success in life science molecular research, in applied and pharma applications, in microscopy and nanoanalysis, and in industrial applications, as well as in cell biology, preclinical imaging, clinical phenomics and proteomics research and clinical microbiology. For more information, please visit:www.energie2point0.com.
About the Yates Lab at TSRI (La Jolla, CA)
Yates实验室中的研究集中在基于质谱的蛋白质组学技术的开发和应用上，以在广泛的生物学问题上。我们的实验室在该领域的发展中发挥了重要作用，使许多具有里程碑意义的进步开创了构成主要蛋白质组学实践的基础的地标进步，包括shot弹枪蛋白质组学（McCormack，A。L。; Schieltz，D。M.; Goode，B。; Yang; Yang; Yang; Yang; Yang; Yang; Yang; Yang，s。; Barnes，G。; Drubin，d。; Yates，J。R.，III。Anal。Chem。1997，69，69，767-776），数据库搜索（Secest，Eng，Eng，J.K。; McCormack，A.L。; Yates，Yates，Yates，J。J. R.III。J.Am。Soc。Soc。Soc。1994，5，976-989）和多维蛋白质鉴定（Mudpit，Washburn，M。P。; Wolters，d。d。; Yates，J。R. R. J. R.242-247）。我们继续动力增加蛋白质组学技术的范围，敏感性和吞吐量及其在生物学问题上的应用。我们的研究涵盖了生物信息学和软件开发，方法开发和生物应用领域。一个实验室中蛋白质组学管道中所有元素的整合促进了所有元素的进步。Yates Lab已发表了700多个同行评审的论文。最近的亮点包括全面的蛋白质组学研究，揭示了与囊性纤维化有关的分子机制以及能够恢复功能到疾病中突变蛋白的蛋白质的鉴定，并研究了包括精神分裂症和抑郁症在内的大脑情感障碍。http://fields.scripps.edu/yates/wp/
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Source: Bruker Corporation