Press Release Details

SAN FRANCISCO, June 20, 2019 /PRNewswire/ -- At the ASM Microbe Conference 2019 (www.asm.org), Bruker launches the newMaldi Biotyper Sirius所有以前已清除FDA的系统，以及所有仅研究使用的系统（RUO）MALDI BIOTYPER（MBT）参考文献，用于微生物学培养物中的近乎宇宙，快速和具有成本效益的微生物鉴定。这Maldi Biotyper Sirius现在，第一次还支持快速抗生素耐药性测试中的新型负极离子模式测定研究和临床研究。这个新的高端系统补充了标准MALDI BIOTYPER和高通量Maldi Biotyper Smart。

这global spreading of antibiotic resistances is a growing healthcare problem, and the development and implementation of new, fast and cost-efficient resistance tests are important for advancing antibiotic stewardship. For gram-negative bacteria, the resistance-problem is so serious in many countries that antibiotics like colistin, with the risk of nephrotoxic side effects, increasingly must be used as an 'antibiotic of last resort'. Antibiotic stewardship aims to de-escalate the therapy in such cases early, if possible, or switch patients to other therapeutic options, if resistance is detected.

现在，可以进一步开发和验证新的，快速检测革兰氏阴性细菌中抗体蛋白抗性的测定法Maldi Biotyper Sirius除了所有常规的临床FDA清除识别测定法外，还在同一仪器上。新的RUO结肠毒素抗性测定法使用脂质分析以负离子模式，并在英国伦敦帝国学院开发（Larrouy-Maumus等人，在ECCMID 2019上发表，提交出版）。

新的Maldi Biotyper Sirius使用专有smartbeam™solid-state laser with a 200 Hz repetition rate, and a lifetime of 500 million shots. This essentially makes thesmartbeama 'lifetime laser' in typical microbiology laboratories. The high-performance vacuum system allows for an even faster exchange of target plates in laboratory workflows, where multiple technicians prepare targets independently. Moreover, the high-performance vacuum system reduces downtime after service or preventive maintenance, which typically can be completed on the same day. TheMBT小天狼星features new electronics, and LED strips indicate the system status. In the RUOMBT小天狼星, polarity switching to negative-ion mode is software-controlled and just takes a minute.

英国伦敦帝国学院的MRC-Centre分子细菌学与感染MRC-Centre的小组负责人Gerald Larrouy Maumus博士评论。“这Maldi Biotyper Sirius是一种多功能的MALDI-TOF MS系统，它不仅能够非常迅速地执行近乎全世界的细菌识别，而且其额外的负离子模式也使我们能够开发出快速且可靠的测定法，以检测抗colistin的细菌作为抗性细菌监管部门批准后的重要，潜在的未来常规测定。正如我的学生所说，新的Maldi Biotyper Siriusis just 'Wow!'"

此外，布鲁克介绍了MBT明星选择性测试碳青霉烯和头孢菌素作为仅研究使用的（RUO）测定的测定法，以支持美国研究和验证研究，以快速检测抗生素耐药性。功能MBT明星assays monitor molecular mass shifts due to the enzymatic metabolization that occurs in the case of bacterial resistance against the beta-lactam class of antibiotics.

两者的时间时间（TTR）MBT明星assays is only about 60 minutes after positive culture. Unlike gene-targeted molecular resistance tests, theMBT明星assays are functional tests that can detect not only known resistance mechanisms, but also new, emerging resistances.

Bruker Daltonics微型生物学和诊断副总裁Wolfgang Pusch博士说：“布鲁克一直在推动多年来在微生物学中广泛实施微生物学的广泛实施。新的工作流程以及MBT明星RUO分析，我们的美国客户现在可以访问重要的，功能性的β-内酰胺酶耐药性的快速功能测定法研究和验证研究。我们很高兴新的Maldi Biotyper Sirius旨在进一步研究革兰氏阴性细菌中快速结肠蛋白耐药性测试，一旦得到充分验证并获得了监管批准，该细菌可能会成为重要的未来临床MBT分析。”

此外，布鲁克介绍了微守年™portfolio of veterinary antibiotic susceptibility tests (AST) to the US market (not for human diagnostic use). The微守年products for veterinary medicine can assist in selecting targeted treatments of microbial infections in companion animals, livestock and horses. The微守年plates analyze true minimum inhibitory concentrations (MIC) by broth microdilution.

真正的MIC测试越来越成为兽医测试中的“黄金标准”。随着抗兽药中抗性细菌的越来越普遍，微守年AST plates help to guide veterinarians with the appropriate selection of antibiotic therapy.Micronaut Vet Comassays support the analysis of bacteria isolated from companion animals, whileMicronaut兽医CSH板可用于从活动物和马中分离出的细菌。Micronaut兽医MAS能够分析引起的细菌中的抗生素耐药性bovine mastitis在乳制品行业。

About the BrukerMALDI BIOTYPER（MBT）平台

这MALDI BIOTYPERenables molecular identification of bacteria, yeasts and fungi from cultures. Classification and identification of microorganisms is achieved reliably and quickly using proteomic fingerprinting by high-throughput MALDI-TOF mass spectrometry. TheMALDI BIOTYPER使用基于细菌菌株的特定蛋白质组学指纹的分子方法。许多已发表的研究强调了更高的准确性和更低的成本，以及通常更快的时间（TTR）。

Applications of variousMALDI BIOTYPER解决方案包括临床和兽医微生物识别，环境和药物分析，分类学研究，食品和消费者产品安全和质量控制以及海洋微生物学。在许多欧洲和国际实验室中，MALDI BIOTYPERhas replaced classical biochemical testing for bacterial identification in the past few years due to its accuracy, speed, extensive species coverage, ease of use and cost effectiveness. Traditional biochemical techniques detect different metabolic properties of microorganisms, can take many hours or even days, and often lack specificity.

坚固的MALDI BIOTYPER需要最少的样品准备，并提供低消耗品的成本。产品的产品MALDI BIOTYPERfamily are available in a research-use-only (RUO) version, as the U.S. FDA-clearedMALDI BIOTYPER CA系统，或根据欧盟指令EC/98/79在IVD-CE版本中。这MALDI BIOTYPER在许多其他国家 /地区也有医疗设备注册。

RUO versions of theMALDI BIOTYPER软件允许选定的高价值抗菌耐药性测试。CE-IVDMBTSTAR®-Cepha套件可以快速，功能性抗生素耐药性测试头孢菌素，和CE-IVDMBT Star-Carbakit is for fast碳青霉烯- 抗性测试。

关于布鲁克公司(Nasdaq: BRKR)

力量使科学家能够做出突破discoveries and develop new applications that improve the quality of human life. Bruker's high-performance scientific instruments and high-value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity and customer success in life science molecular research, in applied and pharma applications, in microscopy and nanoanalysis, and in industrial applications, as well as in cell biology, preclinical imaging, clinical phenomics and proteomics research and clinical microbiology. For more information, please visit:www.energie2point0.com。

投资者联系：
帕梅拉·克拉克（Pamela Clark）
投资者关系
布鲁克公司
t：+1（978）663–3660，分机。1479年
E:[电子邮件保护]

媒体和客户的联系：
Philip Perry
布鲁克·道尔顿学
T： +49-172-313-7216
E:[电子邮件保护]

View original content to download multimedia:http://www.prnewswire.com/news-releases/bruker-launches-maldi-biotyper-sirius-at-asm-microbe-conference-300871836.html

来源布鲁克公司