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The Weizmann Institute of Science Selects Bruker GigaHertz NMR Technology to Enable Advanced Structural Biology Research

April 06, 2016

Weizmann Makes Major Investment in Magnetic Resonance Research Infrastructure with 1 GHz NMR, DNP-NMR and 15 Tesla Preclinical MRI System to Further Accelerate World-Class Research

REHOVOT, Israeland BILLERICA, Mass., April 6, 2016/PRNewswire/ -- The Weizmann Institute of Science in Rehovot, Israeltoday announced major scientific instrument purchases from Bruker(NASDAQ: BRKR), including a novelAeon™1GHznuclear magnetic resonance (NMR) system for expanding frontiers in structural biology and intrinsically disordered protein (IDPs) research. Furthermore, the Weizmann Instituteis adding an永旺600MHz NMR, a263 GHz dynamic nuclear polarization(DNP)-NMRsystem, and aBiospec®15 Teslasystem for preclinical ultra-high field magnetic resonance imaging (MRI). Various NMR and electron paramagnetic resonance (EPR) instrument upgrades round out this major acquisition, instantly propelling the Weizmann Instituteto the frontiers of modern magnetic resonance research infrastructure.

教授Gilad Haran, Dean of the Faculty of Chemistry at the Weizmann Institute of Science

In the 1950s, one of the world's first high resolution NMR systems was conceived at Weizmann Instituteresearchers Alexander and Meiboom, and since then three generations of renowned Weizmann magnetic resonance researchers have played key roles in the development of NMR, EPR and MRI. Going forward, the focus of the Weizmann Institutein magnetic resonance research will be on biomolecular NMR and EPR research for future healthcare applications, metabolomics and preclinical research for cancer diagnostics and neurodegenerative diseases, as well as on advanced research on batteries and advanced materials.

教授 Gilad Haran, Dean of the Faculty of Chemistry at the Weizmann Institute of Science, commented: "In the last 2 years we hired 4 new faculty members specializing in the various branches of MR research. The new instruments will facilitate the research of this world-class group and of their more veteran peers, and will reinforce Weizmann's position as one of the premier centers in the world for MR research."

Werner Maas, Ph.D., the President of the Bruker BioSpin Magnetic Resonance Spectroscopy Division, added: "The adoption of the Aeon 1 GHz NMR platform by the Weizmann Institute进一步验证这一革命性的侦探hnology and its impact on the research of structural biology and intrinsically disordered proteins. We are extremely pleased to partner with the Weizmann Instituteand provide the research tools they need to advance scientific understanding of the bio-molecular processes of many diseases affecting people across the globe, as well as the understanding of advanced materials that will impact many emerging technologies."

TheAeon 1 GHzsystem incorporates the world's first shielded 1 GHz NMR magnet, as well as active refrigeration. Active shielding reduces the space volume occupied by the 5 Gauss stray field of this two-story magnet by more than one order of magnitude, and makes siting of next-generationAeon 1 GHzmagnets straight-forward. TheAeonmagnet series features integrated active refrigeration technology, which eliminates the need for liquid nitrogen, and brings liquid helium boil-off essentially to zero in normal operation. Bi-annual pulse-tube cooler maintenance can be done at field with minimal disruption and down-time.

The263 GHz DNP-NMRspectrometer takes advantage of the dramatic sensitivity enhancements enabled by Dynamic Nuclear Polarization (DNP). The system consists of anAvance™ III HDspectrometer, configured for solid-state NMR, combined with a high-power gyrotron microwave source and a specialized low-temperature DNP/NMR probe in an easy to use, integrated package.

TheBioSpec® 150/11is an ultra-high field MRI scanner for preclinical research on mice that will open new frontiers in molecular and microscopic imaging. Based on Bruker'sproven 15 Tesla horizontalUSR™magnet technology, the system takes advantage of the high signal-to-noise ratio and enhanced contrast mechanisms at high field strength. Exploiting the novel 15 Tesla MRICryoProbe™, the system enables new research onin vivomolecular events in cells.

关于 The Weizmann Institute of Science
The Weizmann Institute of Scienceis one of the world's leading multidisciplinary research institutions. The driving force and spirit that inspired its scientific activities was Dr. Chaim Weizmann, a world-renowned chemist who headed the World Zionist Movementfor many years and served as the first president of the 以色列.

Over the years, the Weizmann Institutehas grown with the country and been the source of a number of Israeli milestones. These range from pioneering work in cancer research to building the county's first electronic computer and the first particle accelerator.

Other Institute firsts include the development and production of Israel'sfirst ethical (original) drug, new computer languages, the solving of the three-dimensional structures of biological molecules involved in health and disease, and many more. The fields range from optics to genetics, from organ transplants from embryonic tissue to the creation of a nano-biological computer.

关于 Bruker Corporation
For more than 50 years, Brukerhas enabled scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. Bruker'shigh-performance scientific research instruments and high-value analytical solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels.

In close cooperation with our customers, Brukeris enabling innovation, productivity and customer success in life science molecular research, in applied and pharma applications, in microscopy, nano-analysis and industrial applications, as well as in cell biology, preclinical imaging, clinical research, microbiology and molecular diagnostics. For more information, please visit:www.energie2point0.com.

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SOURCE Bruker Corporation

Yivsam Azgad, Institute Spokesman, Institute Curator, Director, Department of Media Relations, T: 972 (0)8 934 3856, E:[email protected]; Thorsten Thiel, Ph.D, Director of Marketing Communications, Bruker Corporation, T: 49 (721) 5161-6500, E:[email protected]; Joshua Young, Vice President, IR & Corporate Development, Bruker Corporation, T: 1 (978)-663-3660, ext. 1479, E:[email protected]
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