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Bruker Introduces Innovative timsTOF™ Mass Spectrometer

June 06, 2016

Unique Trapped Ion Mobility Spectrometry (TIMS) Coupled to Bruker's High-Performance QTOF Mass Spectrometry Enables High-Resolution Compound Separation, Significant Duty Cycle Enhancements and Studies of Protein Conformations, Aggregation and Structural Isomers

SAN ANTONIO, June 6, 2016/PRNewswire/ -- At the 64th ASMS Conference, Bruker引入了一个全新的质谱技术平台:创新性Timstof™系统将非常高的离子迁移率分辨率大于200 布鲁克的所有权TrappedIM可及性Spectrometry (TIMS), 布鲁克的ultra-high performance ESI-QTOF mass spectrometry.

新的Timstof是一种灵活的研究级工具,用于最佳分离和分析未分辨的化合物和构象。布鲁克独特的离子移动性扩展(imeXTM) TIMS technology empowers market-leading, highest ion mobility resolution that can be adjusted to research or analytical needs. A novel Open Data Format supports user-created software tools tailored to specific research questions.

In recent years, ion mobility separation has matured into a valuable analytical tool that boosts mass spectrometry analysis in various areas. Ion mobility resolution, however, has been restricted in previous IMS systems by physical size limitations. Bruker's completely unique and proprietaryTimstof系统通过极其强大但非常紧凑的TIMS设备消除了这些权衡和局限性,该设备可实现市场领先的离子移动性分辨率大于200,而无与伦比的分离和IMS研究能力。

Dr. 梅尔文公园自成立以来一直监督Timstof的研究的Bruker Daltonics研究总监,与主要客户合作,纳入了更多的TIMS改进并开发了高级TIMS应用程序。帕克博士说:“全新Timstofsystem takes ion mobility performance to the next level. Years of experience in the application of TIMS design and solid engineering are merged in this novel instrument to set new standards in ion mobility resolution. Our collaborators andTimstof客户将经历前所未有的研究flexibility and exceptional analytical confidence."

Professor Christian Bleiholder在里面 Department of Chemistry & Biochemistryat Florida State University in Tallahassee, FL, added: "Our work focuses on native structure elucidation of proteins and on studying protein-ligand binding events by ion mobility spectrometry – mass spectrometry methods. The high ion mobility resolving power of our timsTOF system, which routinely exceeds 200, increases the confidence in the structural interpretation of our data. Also very important for our work is the ability of TIMS to preserve solution-phase structures, and the ability to trap analyte ions in the TIMS device to monitor structural changes over extended periods of time."

有关timstof system

这所有权timstof s系统提供下一代离子迁移技术,以实现复杂样品中化合物和构象的高清分析。此外 布鲁克的高性能QTOF高质量分辨率,PPM精确质量和高同位素保真度(真同位素模式或尖端TM),TIMS允许分离异构化合物,准确确定碰撞横截面以及气相蛋白结构和聚集研究。此外,TIMS分离的前体离子的破碎化导致了清晰的碎片化光谱,以确定自信的识别。

Dr. Jan Jordens, at DSM Resolve in 这Netherlands,评论:“Timstofgave us more insight into our samples through highest resolution LC-TIMS-MS/MS data right from the beginning. We saw information that we did not even expect. Now, the platform really helps us to get new knowledge about processes that are taking place in our samples and also about unexpected impurities."

供电 布鲁克的离子移动性扩展(IMEX)TIMS技术,可以调整TIMSTOF系统的离子移动性分辨率,以详细检查感兴趣的化合物。这种强大的TIMS灵活性实现了新型工作流程,从而利用了前所未有的TIMS解决能力超过200的能力。

Sensitivity has been restricted in previous devices by the limited duty cycle, which means a significant loss of ions in commonly used ion mobility devices. TheTimstof现在,根据其独特的平行积累能力,系统可以使离子移动性分离,最多可达100%占空比。TIM可以在Timstof在软件控制下,不会丢失QTOF性能。

最大化Timstofresearch flexibility, the platform uses an Open Data Format (*.tdf) that supports tailored analyses based on open source SQLite, thus enabling users to develop their own analytical algorithms. With standardized structure and straightforward access, data fromTimstof很容易地纳入创新数据处理,可视化的新形式和信息丰富的报告。这 Bruker-supplied Data Analysis 5.0 software enables interactive analysis of high-resolution ion mobility data in heat maps, mobilograms, and mass spectra.

Dr. Carlos Afonsoat the Université de Rouen in 法国评论说:“我们已经在实验室中使用了离子移动性,但是具有更高的离子移动性解决方案Timstofprovides now, there is a lot of room for different applications based on this novel technology."

有关 Bruker Corporation
超过50年, Brukerhas enabled scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. 布鲁克的高性能的科学研究工具和高价值分析解决方案使科学家能够在分子,细胞和微观水平上探索生命和材料。bob综合游戏

In close cooperation with our customers, Brukeris enabling innovation, productivity and customer success in life science molecular research, in applied and pharma applications, in microscopy, nano-analysis and industrial applications, as well as in cell biology, preclinical imaging, clinical research, microbiology and molecular diagnostics. For more information, please visit:www.energie2point0.com

Figure 1: Raffinose, Melezitose and Maltotriose have the same elemental composition C18H32O16, but differ in structure: A. timsTOF separates the isomeric trisaccharides with ion mobility resolution of 80. B. imeX technology allows adjusting ion mobility resolution which is increased to 120 in this acquisition. C. imeX ultra mode allows baseline separation of the trisaccharides with ion mobility resolution of 185.

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SOURCE Bruker Corporation

Media Contact:
Christian Ravnsborg
Bruker Daltonics营销解决方案主管
T: 45 2633 2021
E:Christian.ravnsborg@bruker.com

Investor Contact:
Stacey Desrochers
Director, Investor Relations, Bruker Corporation
T: 1 (978)-663-3660
E: Stacey.Desrochers@bruker.com

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