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Bruker Announces Acquisition of Nucleic Acid Testing (NAT) Assays and Syndromic Panel Technology to Expand its MALDI Biotyper™ Platform

November 02, 2016

BILLERICA, Mass., Nov. 2, 2016/PRNewswire/ -- Bruker today announced a technology acquisition in support of its microbiology business and its world-leadingMALDI Biotypermicrobial identification platform. Financial details were not disclosed.

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Brukerhas acquired selected assets in Glasgow, UKfor the development, validation and commercialization of molecular assays for applications in microbiology. Bruker has acquired laboratory infrastructure and IP in the NAT assay field, including real-time PCR assays for microbiology. In parallel, Brukerhas hired an experienced R&D, operations and commercial team in Glasgowto drive PCR-based syndromic panel development for Bruker'sMALDI Biotyperplatform.

TheMALDI Biotyperoffers fast, highly accurate and cost-efficient microbial identification with exceptionally broad species coverage, based on proteomic fingerprinting. Molecular multiplex and syndromic panel testing is another growing field in clinical microbiology. When a rapid, targeted answer is required without prior microbial cultivation, multiplex PCR assays for the identification of selected bacterial, fungal and viral species, and for the fast detection of resistance genes, are highly complementary to broad-coverage, untargeted proteomic identification from isolates after overnight culture. Such proteomic assays and NAT assays are expected to be both performed on the sameMALDI Biotyperplatform. Applications for targeted multiplex PCR assays arise in early screening, confirmation testing and broader syndromic testing.

Dr. Wolfgang Pusch, Executive Vice President for Clinical MALDI Solutions at Bruker Daltonics, commented: "In addition to conventional, targeted real-time PCR assays, Brukersees further advantages in combining multiplexed syndromic PCR assays with a read-out on theMALDI Biotyperplatform. Bruker intends to validate and launch the real-time PCR assays which have been acquired, and develop new multiplex PCR panels on theMALDI Biotyperplatform in order to expand its assay menu to rapid targeted bacterial, fungal and viral identification, to fast antibiotic resistance testing, as well as to syndromic panels. With over 2,000MALDI Biotypersalready installed worldwide for fast, highly accurate and untargeted microbial identification, we are excited to bring new NAT multiplex assay and syndromic panel capabilities to our customers over time."

关于the BrukerMALDI Biotyper

TheMALDI Biotyperfamily of systems enables molecular identification, and taxonomical classification or de-replication of microorganisms like bacteria, yeasts and fungi. Classification and identification of microorganisms is achieved reliably and quickly using proteomic fingerprinting by high-throughput MALDI-TOF mass spectrometry. TheMALDI Biotyperuses proteomic fingerprints from bacterial strains for identification. Published studies have highlighted the greater accuracy, broader coverage and lower cost offered, as well as faster time-to-result (TTR).

Applications of theMALDI Biotyperplatform include clinical routine microbial identification, environmental and pharmaceutical analysis, taxonomical research, food and consumer product safety and quality control, as well as marine microbiology. In many European and international laboratories theMALDI Biotyperhas replaced classical biochemical testing for bacterial identification due to its accuracy, speed, extensive species coverage, ease of use and cost effectiveness. Classical biochemical techniques detect different metabolic properties of microorganisms, can take many hours or even days for completion, and often lack specificity.

The robustMALDI Biotyperworkflow requires minimal sample preparation and offers low consumables cost. The products of theMALDI Biotyperfamily are available in a research-use-only (RUO) version, as the U.S. FDA-clearedMALDI Biotyper CA System, or in an IVD-CE version according to EU directive EC/98/79. TheMALDI Biotyperalso has medical device registrations in numerous other countries. RUO versions of theMALDI Biotyperallow selected high-value antimicrobial resistance tests in translational research, and subtyping capabilities.

关于 Bruker Corporation(NASDAQ: BRKR)

For more than 50 years, Brukerhas enabled scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. Bruker's高性能科学研究工具nd high-value analytical and diagnostic solutions enable customers to explore life and materials at molecular, cellular and microscopic levels.

In close cooperation with our customers, Brukeris enabling innovation, productivity and customer success in life science molecular research, in applied and pharma applications, in microscopy, nano-analysis and industrial applications, as well as in cell biology, preclinical imaging, clinical research, microbiology and molecular diagnostics. For more information, please visitwww.energie2point0.com.

Investor Contact:
Miroslava Minkova
Head of Investor Relations
T: +1 (978) 663–3660, ext. 1479
E:miroslava.minkova@bruker.com

Media Contact:
Dr. Winfried Busch
Bruker Daltonics Microbiology Business
Tel: +49-421-2205-1242
E:Winfried.Busch@bruker.com

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SOURCE Bruker Corporation

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