Skyscan 1276 CMOS版

Skyscan 1276 CMOS Edition是一种高性能，独立的，快速的桌面，体内Microct，具有持续可变的倍率，用于扫描小实验动物（小鼠，大鼠，...）和生物样品。可选的大型动物传输系统（LAT）可用，使系统能够安装在内的大型动物，包括兔子。

1276年SKYSCAN CMOS Edition has an unrivalled combination of high resolution, big image size, round and spiral (helical) scanning and reconstruction, and low dose imaging. The image field of view up to 75 mm wide and 310 mm long allows full body mouse and rat scanning. The variable magnification allows scanning bone and tissue samples with high spatial resolution down to 2.8 µm pixel size. Variable X-Ray energy combined with a range of filters ensures optimal image quality for diverse research applications from lung tissue to bone with metal implants. The system can perform scanning with continuous gantry rotation and in step-and-shoot mode with scanning cycles down to 3.9 sec. Furthermore, the SKYSCAN 1276 CMOS in vivo microCT administers a low radiation dose to the animals allowing multiple scans in longitudinal preclinical studies without the risk of unwanted radiation-induced side effects. The fully integrated physiological monitoring package allows monitoring and controlling the animal's wellbeing at all times through a video stream, ECG, temperature and breathing detection.

Skyscan 1276 CMOS由3D.Suite补充。这种广泛的软件套件涵盖了GPU加速的重建，2D / 3D形态分析，以及表面和体积渲染可视化。

SKYSCAN 1276 CMOS系统提供可更换的动物盒，可用于所有BRUKER IN-VIVO成像仪器，如MRI，微宠物，微观SPECT，生物发光，生物荧光等。它允许共同登记来自同一动物的功能和形态学信息。

The user interface of the SKYSCAN 1276 CMOS system is simple and intuitive. The instrument can be controlled from the computer screen and also from the embedded force-sensitive touchscreen, which can be operated by gloved hands. The touchscreen allows selection of scanning protocol, adjusting the animal bed position and control of imaging and scanning. Where multiple scans are started from the touchscreen, the software will automatically save acquired data to separate subfolders with incrementally assigned folder names and dataset file prefixes.

The SkyScan1276 control software includes a real-time on-screen dose meter. It indicates an estimation of the dose absorbed by the animal body during scanning. The measurement is based on the absorption calculated from X-ray projection images of the animal cross-calibrated with electronic dosimeter measurements. The dose meter shows accumulated dose or dose rate. It is calibrated for X-ray absorption in the standard mouse and rat cassettes. In this way it measures the X-ray dose absorbed in animal body itself during scanning. The dose absorbed by the animal during a scan is documented in the scan log-file together with all scan and reconstruction settings.

生理监测系统包括具有实时移动检测，ECG和呼吸检测的动物的视频监控，以及温度稳定。一台500万像素的彩色摄像机安装在动物床上方，以及白色LED照明，在扫描过程中引入动物的实时图像。该软件从呼吸移动的图像的用户选择区域分析视频流。这些运动被转换成运动波形，以提供用于时间分辨重建的呼吸时间标记。动物床上的面罩连接到空气/气流传感器，用于直接呼吸检测。动物盒中的ECG电极连接到敏感的ECG放大器。呼吸和ECG信号都被数字化并显示为屏幕上的实时配置文件。该监测还包括加热气流的温度稳定，其在所选温度下将扫描动物保持，以防止在麻醉下冷却动物。