Chaperone Compounds for Co-crystallization of Organics

Often in less than one hour our single-crystal X-ray diffraction (SC-XRD) solutions enable high-quality 3D structure analysis – including absolute structure determination. This makesSC-XRDan extremely fast and comprehensive method. However, a large number of small or highly flexible organic molecules remain intractable to established crystallization methods. Our new sets of Chaperones provide access to highly effective co-crystallization, which adds a powerful method to the toolbox of chemists and crystallographers.

• The chaperone method is fast and easy to use
• Structures in hours rather than weeks
• Small quantities of analyte required
• Excellent quality crystals
• Sample screen of 52 organic compounds
  - Diffraction-quality crystals in 88% of cases
  - High resolution X-ray structures in 77% of cases
• The chaperone compounds are highly stable
• 100% analyte occupancy in the crystal guarantees reliable determination of the absolute configuration

Three different sets of Chaperons are currently available:

• 1,3,5,7-Tetrakis(2,4-diethoxyphenyl)adamantane (TEO) P/N A30D250
• 1,3,5,7-Tetrakis(2,4-dimethoxyphenyl)adamantane (TDA) P/N A30D251
• 1,3,5,7-Tetrakis(2-bromo-4-methoxyphenyl)adamantane (TBro) P/N A30D252

In addition to the chaperone each set consists of:

• 30 crystallization vials
• Instruction set on memory stick
• Reference publications

The chaperones can significantly increase the probability of successful crystallization and provide faster access to the absolute 3D structure of an organic analyte.