代谢组科应用

代谢组织的核心是识别与疾病，药物毒性或遗传或环境变异相关的潜在的小分子生物标志物。代谢组学对许多应用领域的研究方式有很高的影响。

Validated biomarkers in clinical research or public health studies can form the basis for new diagnostic assays, and lead the way to help establish truly personalized medicine.

应用在制药研究中的代谢组学可以提供有关药物毒性的早期信息，是药物发现的一个中央目标。

Functional genomics studies to unravel gene functions and interactions in bacterial, plant, animal and human research benefit from metabolic profiling approaches since changes in small molecule concentrations are closely related to the observed phenotype. Metabolomics applied in Nutrition and Food revolutionized the detection of food adulteration and assists breeders in strategic trait optimization.

Also for YOUR metabolomics application Bruker offers class leading solutions to generate answers based on latest innovations for hyphenated NMR, LC-MS, GC-MS and FT-IR technologies.

In clinical research metabolomics strategies are applied in model systems such as cell cultures or animals up to large scale epidemiological studies as these approaches hold great potential to detect new biomarkers for diseases. Validated biomarkers can serve in diagnostics as well as in monitoring drug therapy - ultimately enabling real perzonalized medicine.

Validated biomarkers will also shed light on the molecular basis for diseases and point to novel drug targets, which is of primary importance in pharmaceutical research.

代谢组织在人类健康研究中影响的一个例子是基于NMR的分析中的一个极其有前景的项目，有助于提供新生儿健康状况的现有错误的有效，可靠的筛选。它有可能产生按钮，高吞吐量筛选解决方案，提供同时非目标和有针对性的分析。

除了NMR，Bruker的LC-MS和GC-MS的代谢组件解决方案外，完全符合综合代谢分析的要求，样品吞吐量，生物标志物检测，识别，验证和量化。

The later that a molecule or molecular class is lost from the drug development pipeline, the higher the financial cost. Minimizing attrition is therefore one of the most important aims of a pharmaceutical discovery program.

新颖的技术，增加制定正确选择早期节省资源的概率，促进安全，效率和盈利能力。

Metabolomics is a systems approach for studying in vivo metabolic profiles, which promises to provide information on drug toxicity, disease processes and gene function at several stages in the discovery and-development process.

Pharma，代谢组科，表情，扩张组和非靶向筛查具有不同的目的。但是，与此同说，所有这些学科都享有一些常见的需求，如感兴趣的迅速复制（药物代谢物，可能的生活方式或环境暴露标记）。

The integrated software solutionMetaboscape.^®addresses common needs for advancing pharma, metabolomics, lipidomics, non-target screening and exposome research:

• Biotransformer的局部代谢物预测¹使得可以在Metaboscape中获得安全的药物代谢物注释^®
• 支持Metaboscape的多因素时间课程实验支持药物代谢中代谢途径的半定量描述，并花费媒体分析（BIO）Pharma研究

From raw materials to the final consumer product, the monitoring of the production and distribution cycle of food is of importance with regard to safety, authenticity and quality of food for producers, consumers and regulatory agencies. To achieve this, precise and accurate analytical tools are needed in order to ensure origin, properties, falsification, and reliability of food. The NMR based JuiceScreener is a perfect example how Bruker addressed this need with a push button solution in juice assessment applying a Targeted and Non-Targeted Multi Marker Analysis.

除食物控制外，代谢组种方法还成功地应用于食品和营养特性优化。特别是基于代谢组的研究，以提高营养和品味特征对农业产业的潜力巨大。Bruker的产品组合可以随时能够通过基于互补LC-MS，GC-MS，NMR和FT-IR技术来容易地实现非目标代谢组合方法。

代谢组学对植物生理学研究产生了巨大影响。虽然“古典”植物生物化学已经研究了数十年，但代谢分析的整体方法在许多研究组中发现了它的方式。

非目标方法可以提供有关生物或非生物因素在植物中诱导的意外代谢变化的重要信息，以及在功能基因组学研究中的解开基因功能。

These non-targeted as well as targeted approaches are readily enabled by Bruker's Metabolomics solutions. In particular the combination of complementary technologies such as NMR, LC-MS and GC-MS perfectly address the need for a comprehensive analysis of small molecules.

代谢组学工作流程的组成部分是Bruker´s tailored software to quickly pinpoint relevant information and generate knowledge.

微生物具有长期的传统，作为生物活性小分子的源，称为“次级代谢物”。除了活动引导的隔离之外，基于代谢组的策略在揭示额外的天然产品方面越来越成功。这些方法对来自细菌和真菌菌株的新型次生代谢产物具有很大的希望。生物活性化合物的实例是靶向抗性病原体的新型抗生素。

Microorganisms are used in industrial scale production of biologically active small molecules, as well as other target compounds like amino acids and vitamins used e.g. for food supplementation. In order to increase the production of the desired product metabolomics is often applied to direct rational strain design based on genetic engineering. This approach often goes in hand with functional genomics studies to unravel gene functions in basic research. In summary metabolomics has become an integral part in microbial research.

布鲁克的LC-MS.,GC-MS和NMR基础的代谢组件解决方案完全符合综合代谢分析，样品吞吐量，复合鉴定，验证和量化的要求。